Influence of the technogenic environmental pollution on the effectiveness of vaccination in children
Published: 05.01.09 Updated: 05.01.2009 16:17:53
Ilina S. Influence of the technogenic environmental pollution on the effectiveness of vaccination in children [thesis synopsis]. Irkutsk: Research centre for medical ecology; 2008.
According to the information from the Higher Attestation Commission, S.V. Ilina defended her doctoral thesis on 23 May 2008. The title of the thesis was “Influence of the technogenic environmental pollution on the effectiveness of vaccination in children”. The purpose of the thesis was to evaluate the impact of the technogenic pollution on clinical, epidemiological and immunological manifestations of vaccine preventable infections in children. The author analyzed the incidence of vaccine preventable airborne infections and vaccination coverage on the territories with different levels of technogenic environmental pollution; described clinical and laboratory features of these infections; performed a comparative analysis of clinical and laboratory findings in children vaccinated and non-vaccinated against whooping cough; estimated levels of specific antibodies to certain vaccine preventable infections in children residing on the studied territories and investigated the influence of the ecological problems on postvaccinal immunity to different types of vaccines.
The author concludes that technogenic environmental pollution is an independent factor with negative influence on the studied outcomes. Healthy children’s immune system in the polluted areas is characterized by deprivation of the cell-mediated immunity and phagocyte immunity and by elevation of the serum immunoglobulins. Additional antigenic stimulation (infectious disease) leads to deprivation of all steps of immunity. The incidence of acute respiratory infections and rubella is higher on highly polluted territories compared to control territories and is characterized by shorter temporal cycles and unstable cycle of the epidemic process.
The author reports that technogenic environmental pollution worsens clinical features of both vaccine preventable and non-preventable airborne infectious diseases. The influence of environmental pollution on clinical and laboratory features of infectious diseases is more pronounced in non-vaccinated than in vaccinated children. Effectiveness of vaccination against diphtheria and whooping cough is lower on the territories with high levels of environmental pollution. The influence of pollution on the effectiveness of vaccination is greater for whooping cough, diphtheria, measles and type 3 poliovirus than for tetanus.
The full text of the thesis synopsis in Russian is available here.