Urogenital chlamydiosis: clinico-immunogenetic markers, issues of prognosis and treatment
Published: 04.11.08 Updated: 04.11.2008 16:12:00
Koshkin S. Urogenital chlamydiosis: clinico-immunogenetic markers, issues of prognosis and treatment [thesis synopsis]. Moscow: Central Research Institute of Dermatovenerology; 2008.
According to the information from the Higher Attestation Commission, S.V. Koshkin defended his doctoral thesis on 14 of May 2008. The title of the thesis is “Urogenital chlamydiosis: clinico-immunogenetic markers, issues of prognosis and treatment”. The aims of the study were: to develop criteria for prognosis of individual susceptibility to urogenital chlamydiosis, characteristics of its clinical course, including immune changes among patients using tissue typing techniques; to study haptoglobin types, erythrocyte antigens of the ABO system; to assess epidemiological significance of urogenital chlamydiosis in the structure of sexually transmitted infections; to optimize diagnostic and therapeutical methods and to study the prevalence of HLA antigens among patients with urogenital chlamydiosis in order to define HLA markers associated with susceptibility to the infection.
The author concludes that urogenital chlamydiosis is a socially significant disease; the most common urogenital infection in Kirov oblast is Chlamydia trachomatis; polymerase chain reaction has higher sensitivity than the direct immunofluorescence method in Clamydia trachomatis infection diagnostics. The author found that blood type B (III) was more common among men with clinical symptoms of urogenital chlamydiosis, while AB (IV) blood type was more common among men with asymptomatic infection. The author also found lower proportion of type 2-1 haptoglobin among patients with clinical symptoms of Chlamydia infection than among healthy people. The author also concludes that individuals with DRB1*12 have some resistance to Chlamydia infection. The author reports that HLA B17, B16 and a combination of A1-B16 increase the risk of the disease by 1.9, 2.0 and 6.2 times, respectively.
The full text of the thesis synopsis in Russian is available here.