Prevalence of herpes simplex viruses type 1 and type 2 in Siberia: a population-based study
Published: 05.12.08 Updated: 05.12.2008 14:06:08
Khryanin AA, Reshetnikov OV. Prevalence of herpes simplex viruses type 1 and type 2 in Siberia: a population-based study. Rossijskij zhurnal kozhnyh i venericheskih boleznej. Prilozhenie “Gerpes” (Russian Journal of Skin and Sexually Transmitted Diseases. Supplement “Herpes”) 2008; 1:9-13.
A. A. Khryanin & O. V Reshetnikov studied the prevalence of herpes simplex viruses type 1 and type 2 in the adult population of Siberia. A random sample of 256 adults in the age group 25-65 years was drawn from one of the districts of the city of Novosibirsk. In addition, 100 and 87 randomly selected adults from the rural areas of Tuva and Altay Republics, respectively, were included in the sample. Serum IgG antibodies to herpes simplex viruses both type 1 and type 2 were studied using enzyme-linked immunosorbent assay “Vectro HSV1-2 IgG” produced by Vector-Best Company, Novosibirsk, Russia.
Moreover, the authors studied the prevalence of IgG antibodies to Chlamydia trachomatis, Ureaplasma urealiticum, Mycoplasma hominis, Trichomonas vaginalis, Gardnerella vaginalis, Candida albicans and cytomegalovirus among persons who had IgG antibodies for herpes simplex type 2. In addition, associations between the presence of antibodies to herpes simplex virus type 2 and serological markers of opistorchiasis, toxoplasmosis and rubella were studied.
Altogether, 99.4% of the study participants were positive for IgG antibodies to herpes simplex type 1. There were no difference in the prevalence of IgG antibodies to herpes simplex type 1 between the urban and the rural areas, gender or age-groups.
The prevalence of IgG antibodies to herpes simplex type 2 was 20.3% in the total sample. Women were more likely than men to have IgG antibodies to herpes simplex type 2 in both urban (28.4% vs. 17.0%) and rural (23.5% vs. 7.9%) areas. The prevalence of IgG antibodies to herpes simplex type 2 increased from 18.6% in the age-group 25-44 years to 25.2% in the age group 45-54 years and decreased to 18.5% in the oldest age-group. No differences in the prevalence of IgG antibodies to herpes simplex type 2 by geographical area were observed.
Those who were positive for IgG antibodies to herpes simplex type 2 were also more likely to have IgG antibodies to cytomegalovirus, Candida albicans, Mycoplasma hominis, Chlamydia trachomatis, Trichomonas vaginalis, Ureaplasma urealyticum than those who were negative. No associations with serological markers of opistorchiasis, toxoplasmosis, gardnerellosis or rubella were found.
The authors conclude that almost all Siberian adults aged 25-64 years are infected by herpes simplex virus type 1 while the prevalence of IgG antibodies to herpes simplex type 2 is about 20%. Women are more likely to have type 2 herpes simplex infection than men and the highest prevalence of the infection is in the age-group 45-54 years. The authors also conclude that the overall prevalence of herpes simplex type 2 in Siberia as well as its distribution by age and gender is similar to the one in the USA and Scandinavian countries.