Toxoplasma infection rates in women with obstetric and gynaecological diseases
Published: 04.11.08 Updated: 18.11.2008 13:03:32
Danilenko YeD, Goncharov DB, Kazaryan SM, et al. Toxoplasma infection rates in women with obstetric and gynaecological diseases. Epidemiologia i Infektsionnye Bolezni (Epidemiology and Infectious Diseases) 2008; 1: 11-14.
Danilenko et al. studied the prevalence of toxoplasmosis among women of reproductive age in the town of Cheboksary. The aim of the study was to elucidate the role of this infection in obstetric-gynaecological diseases. Altogether, 28, 18 and 54 women in first, second and third trimesters of uncomplicated pregnancies, respectively, were included in the study as well as 40 non-pregnant women with a history of spontaneous abortion, 40 non-pregnant women with a history of three or more miscarriages and 40 women with infertility. The reference group consisted of 100 blood donors, of which 50 were males and 50 were healthy non-pregnant women.
The serum samples of the above groups were tested for Toxoplasma-specific IgG and IgM antibodies by enzyme immunoassay. In the reference group, the IgG antibodies were detected in 58.0 %, while among pregnant women this proportion was on average 47.0 %. Among women with a history of the abovementioned diseases, IgG antibodies were detected in 36.7 % of samples. Among women with a history of obstetric-gynaecological diseases, IgM-antibodies were detected 4.6 times more often than among female blood donors (9.2% vs. 2.0 %) and 9.2 times higher than among women with uncomplicated pregnancy (9.2% vs. 1.0 %).
The authors conclude that toxoplasmosis plays an important role in the development of the studied diseases, and that there is a need for preventive and therapeutic measures to combat this infection. The authors recommend performing complex laboratory investigation for toxoplasma infection among pregnant women.